关键词: 畸变子模式, 相似性学习, 半定规划, 序列识别

Abstract:

In the domain of sequence recognition, sequences with the same label are not rigorously similar because of the influence of many factors. Using multiscale to measure the similarities between signature sequences is much helpful to obtaining  highlyqualified similarity measures. A new method for sequence recognition based on distorted subsequence is put forward in this paper. A kernel function, which takes into account the distortions of various degrees, is defined on the feature space spanned by the distorted subsequences, and an efficient algorithm of linear cost is designed to compute the feature vectors with high dimensions. A combination of the kernel matrix with different distortions is learned and optimized through Semidefinite Program (SDP). Combining the optimized kernel with Support Vector Machine (SVM), a classifier with softer boundary that allows the most appropriate degree of distortions within the sequences is built. The experiments on the benchmark database of SCOP 1.37 PDB90 show that the classifier improves the recognition accuracy universally for most protein sequences in the 33 families of the benchmark database.

Key words: distorted subsequence;similarity learning;semidefinite program;sequence recognition