Python programming language, as the most popular language tool in the application of large data analysis and processing, has been favored by more and more universities. It mainly cultivates students’ ability of using computer programming to solve practical problems. Based on the current teaching situation of information management and information system specialty in Neusoft Institute Guangdong, with outcomes-based education concept, the existing problems in teaching design and methods of this course is analyzed and its the mixed teaching method is explored. This paper provides a reference for improving the teaching quality of “Python programming language” course and the development of information management specialty.