In order to help small and medium enterprises (SMEs) face the global challenges, the definition of “cluster supply chain” is put forward as a new type of management pattern, which is the combination of industrial cluster and supply chain management. However, the related research on cluster supply chain is still in its infancy, and it is difficult to put theoretical results into practice. Based on this background, the paper presents an agent oriented analytic framework to bridge the gap between theory and practice in the field. In the end, we provide a pattern for guiding the construction and development of cluster supply chain.