In order to solve the problems of data delay and distributed IT resources, more and more companies put the server and the application from the remote branches to the data center in order to do centralized management. This leads to more and more IT resources in the data center, and the scale of the data center tends to be larger. The data center manages not only the traditional minicomputers, servers, databases and various applications, but also storage equipments, blades servers, virtualization and cloud computing. In this way, the traditional network management and monitoring faces great challenges. This paper describes the comprehensive monitoring and efficient management of server clusters in complex network environments, and focuses on the research of monitoring largescale and multitype data in the data center. The cloud monitoring and management system is made up with data collection and massive data monitoring, It can achieve effective management and comprehensive monitoring of 1 000~10 000 servers. Currently, it can monitor five categories of hosts, for instance, Windows, Linux, Unix, IBM, and Solaris, and seven kinds of applications, such as mySQL, SQLServer, Oracle, Aapache, Tomcat, IIS, site monitoring, etc.