Many-core processors are suitable for accelerating high-throughput computingintensive applications, while cryptography algorithms require large amounts of mathematical calculations and hence require high-throughput computing platforms. This paper proposes a coarse-grained parallel acceleration framework for many-core computing platforms. The framework does not take into account the internal computing process of the algorithm, and allocates the data to the many-core coprocessor for execution in units of computational functions. Based on the MIC many-core accelerator, the framework adopts the three-level parallel structure and task allocation mechanism, and develops the parallelism of the high-throughput cryptography algorithm. Experimental results for a variety of algorithms show that the framework can make full use of many-core computing platforms to achieve high-throughput encryption and decryption processing coarse-grained parallelism.