In order to improve the performance of wireless networks against pollution attack, we propose a wireless network anti-pollution attack scheme based on message authentication and homomorphic signature. Firstly, we use the source node, nonsource node set and link set of the directed multi-graph to construct the model of wireless network coding process, and establish a network anti-pollution model based on data pollution attack and label pollution attack. Secondly, using MACs, D-MACs and the Sign homomorphic signature scheme to establish a hybrid homomorphic signature scheme, which can  improve the message verification process of the anti-pollution attack model, ensure the integrity of the content of each MAC coded packet, and improve the execution efficiency of the algorithm. Finally, experiments under the simulation environment of the ASNC mechanism verify the performance advantage of the proposed algorithm  from three perspectives, which are the percentage of contaminated nodes, cumulative distribution of traffic and calculation efficiency.