Carrying out the comprehensive teaching reform practice of “university computer foundation” course is an important measure to implement the requirements of the new syllabus and do the teaching activities strictly according to the syllabus. The curriculum reform advances comprehensively from top to bottom in five aspects: curriculum teaching objectives, curriculum content, teaching methods, assessment and teaching implementation. It achieves the goal setting of the comprehensive system, innovative and integrated content setting, dynamic and vivid method design, continuous assessment and evaluation throughout the course, and flexible teaching implementation at different levels. Through the two-stage reform practice exploration, it is found that the curriculum reform practice can fully cover the content requirements of the new syllabus, the students put more energy, their assessment results are improved obviously, and their innovation ability is enhanced significantly, so as to achieve the expected goal of reform. It has reference significance for the curriculum reform of other military academies.