Based on the TOPCARES-CDIO education concept, aiming at the problems that the teaching objective is disconnected with post requirements, the learning time is allocated unreasonably, and the examination model is single in the traditional teaching mode of “MCU principles and interfaces”, this paper explores the teaching reform based on TOPCARES-CDIO from knowledge structure, teaching content, teaching methods and evaluation, in order to train outstanding MCU engineers with all-round capabilities for the society.