Computational thinking is one of the basic qualities that contemporary college students should possess, and “university computer foundation” course is an important way to cultivate the computational thinking ability of non-computer majors in colleges and universities. In view of the current situation and existing problems in the teaching of “university computer foundation” course, this paper discusses the reform practice of  “university computer foundation” course in terms of teaching mode, teaching method, experiment and examination, aiming at the cultivation of computational thinking ability.